SNPmeta2-检索式

其明技术专家 meta分析, 博客, 基础科研 2017年5月3日

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第1章：亚甲基四氢叶酸还原酶（MTHFR）多态性与非酒精性脂肪性肝病（NAFLD）之间的关联风险：meta分析

Man-Yi Sun, Li Zhang, Song-Li Shi, Jing-Na Lin

Published: April 29, 2016http://dx.doi.org/10.1371/journal.pone.0154337

http://dx.doi.org/10.1371/journal.pone.0154337

全文地址：http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0154337

Methods

Searching strategy

A computerized literature search was performed from the electronic databases, including PubMed, Excerpta Medica Database (EMBASE), Cochrane Central Register of Controlled Trials (CENTRAL), Web of Science (WOS), China National Knowledge Infrastructure (CNKI)/WANFANG, Scopus and EBSCOhost in April 1st, 2016. There was no language or region restriction. The combinations of following keywords were used: “Methylenetetrahydrofolate Reductase (NADPH)” or “Methylene-THF Reductase (NADPH)” or “MTHFR” or “Methylenetetra hydrofolate Reductase”; “Non-alcoholic Fatty Liver Disease” or “NAFLD” or “Fatty Liver, Nonalcoholic” or “Livers, Nonalcoholic Fatty” or “Nonalcoholic Fatty Livers” or “Nonalcoholic Steatohepatitis” or “Nonalcoholic Steatohepatitides” or “Steatohepatitides, Nonalcoholic” or “Steatohepatitis, Nonalcoholic”; “Polymorphism, Genetic” or “Genetic Polymorphisms” or “Genetic Polymorphism” or “Polymorphism (Genetics)” or “Polymorphisms, Genetic”. The full details of databases searching terms were also provided

检索策略（正文）

从电子数据库，包括PubMed，EMBASE，Cochrane试验中心（CENTRAL），Web of Science（WOS），CNKI/ WANFANG，Scopus和EBSCOhost在2016年4月1日。没有语言或地区的限制。使用以下关键词的组合：“亚甲基四氢叶酸还原酶（NADPH）”或“亚乙基-THF还原酶（NADPH）”或“MTHFR”或“亚甲基四氢叶酸还原酶”; “非酒精性脂肪性肝病”或“NAFLD”或“脂肪肝，非酒精性”或“肝脏，非酒精性脂肪肝”或“非酒精性脂肪肝”或“非酒精性脂肪性肝炎”或“非酒精性脂肪肝”或“非酒精性脂肪肝，非酒精性脂肪肝”脂肪性肝炎，不含酒精”;“多态性遗传”或“遗传多态性”或“遗传多态性”或“多态性（遗传学）”或“多态性，遗传”）

#第二部分检索式###########

Databases searching terms

(updated to April 1^st, 2016)

(1) Pubmed Database (n=10)

#1：((((((Methylenetetrahydrofolate Reductase (NADPH2)) OR Methylenetetrahydrofolate Reductase (NADPH)) OR Methylene-THF Reductase (NADPH)) OR Methylenetetrahydrofolate Reductase) OR 5,10-Methylenetetrahydrofolate Reductase (NADPH)) OR Methylene Tetrahydrofolate Reductase) OR Tetrahydrofolate Reductase, Methylene -----5036

#2：(((((((((((Non-alcoholic Fatty Liver Disease) OR Non alcoholic Fatty Liver Disease) OR NAFLD) OR Nonalcoholic Fatty Liver Disease) OR Fatty Liver, Nonalcoholic) OR Fatty Livers, Nonalcoholic) OR Nonalcoholic Fatty Liver) OR Nonalcoholic Fatty Livers) OR Nonalcoholic Steatohepatitis) OR Nonalcoholic Steatohepatitides) OR Steatohepatitides, Nonalcoholic) OR Steatohepatitis, Nonalcoholic----- 12742

#1 and #2: (((((((((((((Non-alcoholic Fatty Liver Disease) OR Non alcoholic Fatty Liver Disease) OR NAFLD) OR Nonalcoholic Fatty Liver Disease) OR Fatty Liver, Nonalcoholic) OR Fatty Livers, Nonalcoholic) OR Nonalcoholic Fatty Liver) OR Nonalcoholic Fatty Livers) OR Nonalcoholic Steatohepatitis) OR Nonalcoholic Steatohepatitides) OR Steatohepatitides, Nonalcoholic) OR Steatohepatitis, Nonalcoholic)) AND (((((((Methylenetetrahydrofolate Reductase (NADPH2)) OR Methylenetetrahydrofolate Reductase (NADPH)) OR Methylene-THF Reductase (NADPH)) OR Methylenetetrahydrofolate Reductase) OR 5,10-Methylenetetrahydrofolate Reductase (NADPH)) OR Methylene Tetrahydrofolate Reductase) OR Tetrahydrofolate Reductase, Methylene) -----10

(2) EMBASE Database (n=29)

#1 ('Methylenetetrahydrofolate Reductase' OR 'MTHFR') AND ('nonalcoholic fatty liver' OR 'NAFLD' OR 'Nonalcoholic Fatty Liver Disease' OR 'Nonalcoholic Steatohepatitis' OR 'Nonalcoholic Steatohepatitides') AND ('polymorphism' OR 'Genetic Polymorphism' OR 'variants' OR 'variant' OR 'mutation' OR 'mutations' OR 'SNP' OR 'Single Nucleotide Polymorphism') -----32

#1 AND limit 1 to human-----29

(3) Cochrane Central Register of Controlled Trials (CENTRAL) Database (n=0)

#1： MeSH descriptor: [Methylenetetrahydrofolate Reductase (NADPH2)] explode all trees-----166

#2： MeSH descriptor: [Polymorphism, Genetic] explode all trees-----3350

#3： MeSH descriptor: [Non-alcoholic Fatty Liver Disease] explode all trees-----134

#4：#1 and #2 and #3-----0

(4) Web of Science (WOS) Database (n=24)

TS=((((((((((((((Non-alcoholic Fatty Liver Disease) OR Non alcoholic Fatty Liver Disease) OR NAFLD) OR Nonalcoholic Fatty Liver Disease) OR Fatty Liver, Nonalcoholic) OR Fatty Livers, Nonalcoholic) OR Nonalcoholic Fatty Liver) OR Nonalcoholic Fatty Livers) OR Nonalcoholic Steatohepatitis) OR Nonalcoholic Steatohepatitides) OR Steatohepatitides, Nonalcoholic) OR Steatohepatitis, Nonalcoholic)) AND (((((((Methylenetetrahydrofolate Reductase (NADPH2)) OR Methylenetetrahydrofolate Reductase (NADPH)) OR Methylene-THF Reductase (NADPH)) OR Methylenetetrahydrofolate Reductase) OR 5,10-Methylenetetrahydrofolate Reductase (NADPH)) OR Methylene Tetrahydrofolate Reductase) OR Tetrahydrofolate Reductase, Methylene)) -----24